Here is a helpful description of a problem that can be encountered on Linux using the NUMA (Non-Uniform Memory Architecture), often seen with MySQL.
In a nutshell, the machine may bog down with memory-swapping when total memory use is far below what is available, because the default policy is for a processor to prefer the memory in its own node even when swapping occurs.
The simplest solution is to use numactl --interleave.
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